Fleuron WISE (Water Invisible Soft Elastomer) is a UV-curable, water-index-matched polymer designed for optical clarity in aqueous imaging. With a refractive index closely matched to water (~1.33), WISE effectively “disappears” when submerged—minimizing optical aberrations and enabling sharp, high-resolution visualization of biological samples.
Supplied as a liquid that cures under UV light, WISE can be easily cast and molded into micron-scale features. Once cured, it forms a soft, mechanically flexible elastomer, making it well suited for microstructured devices, custom sample chambers, and biological environments where material compliance is important. WISE is engineered to support demanding visible-light super-resolution methods, where even slight refractive-index mismatch can degrade image quality.
In addition to its optical performance and mechanical flexibility, WISE is inert and biocompatible, with low water permeability and negligible small-molecule sorption. The polymer also exhibits minimal swelling in most organic solvents. Its gas permeability (O₂/CO₂) further supports live-sample applications.
Whether you’re building next-generation imaging platforms or optimizing sample interfaces in aqueous environments, WISE provides the optical clarity, softness, moldability, and biological compatibility needed for advanced imaging applications.
WISE can be easily cast and molded into micron-scale features, making it ideal for microstructured devices, custom sample chambers, and precision imaging workflows.
WISE is engineered for demanding visible-light and super-resolution imaging, where even slight refractive-index mismatch can degrade image quality. Reduce optical aberrations and improve image quality with Fleuron™ WISE.
